Every protein is unique. This is commonly heard in the industry, often as an excuse when an upstream development project fails. But if every protein is unique, why do we keep trying to match a single expression vector to every single gene? If every protein is unique, they require unique vectors for optimal production.
In Vectron we already develop tailor-made expression vectors through the combination of proprietary vector elements from our genetic expression libraries. This results in unique expression vectors that give higher titers than what can usually be achieved with conventional expression vectors that are not optimized for every protein.
Vectron is now taking this approach one step further. An evolutionary step.
In VB EVOLUTIONwe evolve new expression vectors. We do this by leveraging our deep understanding of the architecture of the XylS/Pm expression cassette to generate libraries of millions of randomized expression cassettes which we then screen for maximal production of the target protein. By doing this, we can discover novel expression cassettes that would otherwise never be designed, but that are particularly suited for the expression of specific genes.
VB Evolution is only possible due to our extensive understanding of the XylS/Pm expression cassette and our development of an innovative high-throughput (HTP) screening method that allows us to quickly find the one vector that is optimal for each and every gene - the one in a million. The HTP screening method is universal and can be applied to any protein without any necessary optimizations.